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Article

Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.

Genes & development - 15 Apr 1994

Westaway D, Zuliani V, Cooper C M, Da Costa M, Neuman S, Jenny A L, Detwiler L, Prusiner S B

Abstract excerpt

Natural scrapie has been viewed both as a recessive trait and as a contagious disease modulated by a host locus. To address this conundrum, we determined the structure of the sheep prion protein (PrP) gene, which contains three exons and extends over 20 kb of DNA. In the United States 86.4% of scrapie cases occur in Suffolk sheep, and within this breed 49 +/- 6% (+/- S.D., n = 69) of healthy animals carry one or...

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Source

Identifiers

PMID: 7926780
DOI: 10.1101/gad.8.8.959

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.PMID 7926780Read ↗

Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland.Semantic proximity Read ↗

Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie.Semantic proximity Read ↗

The incidence of genotypes at codon 171 of the prion protein gene (PRNP) in five breeds of sheep and production traits of ewes associated with those genotypes.Semantic proximity Read ↗

PrP gene polymorphism in sheep breeds in Slovakia and susceptibility to scrapie.Semantic proximity Read ↗

Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.Semantic proximity Read ↗

Development and usefulness of new polymerase chain reaction-based tests for detection of different alleles at codons 136 and 171 of the ovine prion protein gene.Semantic proximity Read ↗

A real-time polymerase chain reaction assay to detect single nucleotide polymorphisms at codon 171 in the prion gene for the genotyping of scrapie susceptibility in sheep.Semantic proximity Read ↗

Prolonged incubation time in sheep with prion protein containing lysine at position 171.Semantic proximity Read ↗

Biology of PrPsc accumulation in two natural scrapie-infected sheep flocks.Semantic proximity Read ↗

Detection of polymorphisms in the prion protein gene in a population of Irish Suffolk sheep.Semantic proximity Read ↗

Natural scrapie and PrP genotype: case-control studies in British sheep.Semantic proximity Read ↗

Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.Semantic proximity Read ↗

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