Article
Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie.
Genes & development - 15 Apr 1994
Westaway D, Zuliani V, Cooper C M, Da Costa M, Neuman S, Jenny A L, Detwiler L, Prusiner S B
Abstract excerpt
Natural scrapie has been viewed both as a recessive trait and as a contagious disease modulated by a host locus. To address this conundrum, we determined the structure of the sheep prion protein (PrP) gene, which contains three exons and extends over 20 kb of DNA. In the United States 86.4% of sc...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- Exons
- Female
- Genetic Predisposition to Disease
- Glutamine
- Homozygote
- Male
- Models, Genetic
- Molecular Sequence Data
- Polymorphism, Genetic
- PrPSc Proteins
- Promoter Regions, Genetic
- Scrapie
- Sequence Analysis, DNA