Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep.

Journal of virology - 15 Jan 2016

Langeveld J P M, Jacobs J G, Hunter N, van Keulen L J M, Lantier F, van Zijderveld F G, Bossers A

Abstract excerpt

UNLABELLED: Susceptibility or resistance to prion infection in humans and animals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's modulating role has not been well investigated. Compared to disease incubation times in wild-type homozygous ARQ/ARQ (where each triplet represents the amino acids at codons 136, 154, and 171, respectively) sheep, scrapie susceptibility is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to PRNP gene
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Prions

Share to Scrapie

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 26512080
DOI: 10.1128/JVI.02316-15
PMCID: PMC4702698

Genes

PRNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prion Type-Dependent Deposition of PRNP Allelic Products in Heterozygous Sheep.PMID 26512080Read ↗

Proteinase K-resistant material in ARR/VRQ sheep brain affected with classical scrapie is composed mainly of VRQ prion protein.Semantic proximity Read ↗

Classic scrapie in sheep with the ARR/ARR prion genotype in Germany and France.Semantic proximity Read ↗

Susceptibility of sheep for scrapie as assessed by in vitro conversion of nine naturally occurring variants of PrP.Semantic proximity Read ↗

A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes.Semantic proximity Read ↗

Influence of polymorphisms in the prion protein gene on the pathogenesis and neuropathological phenotype of sheep scrapie after oral infection.Semantic proximity Read ↗

Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie.Semantic proximity Read ↗

Resistance to scrapie in PrP ARR/ARQ heterozygous sheep is not caused by preferential allelic use.Semantic proximity Read ↗

Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie.Semantic proximity Read ↗

Sheep scrapie susceptibility-linked polymorphisms do not modulate the initial binding of cellular to disease-associated prion protein prior to conversion.Semantic proximity Read ↗

Absolute and relative quantification of sheep brain prion protein (PrP) allelic variants by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry.Semantic proximity Read ↗

Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.Semantic proximity Read ↗

Risk of scrapie in British sheep of different prion protein genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.