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Article

Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie.

The Journal of general virology - 1 Mar 1995

Belt P B, Muileman I H, Schreuder B E, Bos-de Ruijter J, Gielkens A L, Smits M A

Abstract excerpt

Scrapie is a fatal neurodegenerative disease of sheep that belongs to the group of prion diseases found in humans and animals. The host encoded prion protein (PrP) plays a central role in the disease process. In the PrP genes of man, mice and sheep, polymorphisms have been found that are associated with disease susceptibility and pathogenesis. We have used denaturing gradient gel electrophoresis (DGGE) to detect...

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PMID: 7897344
DOI: 10.1099/0022-1317-76-3-509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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