Article
Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie.
The Journal of general virology - 1 Mar 1995
Belt P B, Muileman I H, Schreuder B E, Bos-de Ruijter J, Gielkens A L, Smits M A
Abstract excerpt
Scrapie is a fatal neurodegenerative disease of sheep that belongs to the group of prion diseases found in humans and animals. The host encoded prion protein (PrP) plays a central role in the disease process. In the PrP genes of man, mice and sheep, polymorphisms have been found that are associat...
Topics
- Alleles
- Animals
- Base Sequence
- Cloning, Molecular
- Codon
- DNA Mutational Analysis
- Electrophoresis, Polyacrylamide Gel
- Genetic Markers
- Genotype
- Molecular Sequence Data
- Nucleic Acid Denaturation
- Point Mutation
- Polymorphism, Genetic
- Prions
- Scrapie
- Sheep