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Article

Lethal mutagenesis of foot-and-mouth disease virus involves shifts in sequence space.

Journal of virology - 1 Dec 2011

Perales Celia, Henry Michel, Domingo Esteban, Wain-Hobson Simon, Vartanian Jean-Pierre

Abstract excerpt

Lethal mutagenesis or virus transition into error catastrophe is an antiviral strategy that aims at extinguishing a virus by increasing the viral mutation rates during replication. The molecular basis of lethal mutagenesis is largely unknown. Previous studies showed that a critical substitution in the foot-and-mouth disease virus (FMDV) polymerase was sufficient to allow the virus to escape extinction through...

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Identifiers

PMID: 21917974
DOI: 10.1128/JVI.00716-11
PMCID: PMC3209394

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Source receipt: pubmed, retrieved 7 Sept 2026.

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