Article
Molecular dissection of a viral quasispecies under mutagenic treatment: positive correlation between fitness loss and mutational load.
The Journal of general virology - 1 Apr 2013
Arias Armando, Isabel de Ávila Ana, Sanz-Ramos Marta, Agudo Rubén, Escarmís Cristina, Domingo Esteban
Abstract excerpt
Low fidelity replication and the absence of error-repair activities in RNA viruses result in complex and adaptable ensembles of related genomes in the viral population, termed quasispecies, with important implications for natural infections. Theoretical predictions suggested that elevated replication error rates in RNA viruses might be near to a maximum compatible with viral viability. This fact encouraged the...
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