Article
Molecular and Functional Bases of Selection against a Mutation Bias in an RNA Virus.
Genome biology and evolution - 1 May 2017
de la Higuera Ignacio, Ferrer-Orta Cristina, de Ávila Ana I, Perales Celia, Sierra Macarena, Singh Kamalendra, Sarafianos Stefan G, Dehouck Yves, Bastolla Ugo, Verdaguer Nuria, Domingo Esteban
Abstract excerpt
The selective pressures acting on viruses that replicate under enhanced mutation rates are largely unknown. Here, we describe resistance of foot-and-mouth disease virus to the mutagen 5-fluorouracil (FU) through a single polymerase substitution that prevents an excess of A to G and U to C transitions evoked by FU on the wild-type foot-and-mouth disease virus, while maintaining the same level of mutant spectrum...
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