Article
A multi-step process of viral adaptation to a mutagenic nucleoside analogue by modulation of transition types leads to extinction-escape.
PLoS pathogens - 26 Aug 2010
Agudo Rubén, Ferrer-Orta Cristina, Arias Armando, de la Higuera Ignacio, Perales Celia, Pérez-Luque Rosa, Verdaguer Nuria, Domingo Esteban
Abstract excerpt
Resistance of viruses to mutagenic agents is an important problem for the development of lethal mutagenesis as an antiviral strategy. Previous studies with RNA viruses have documented that resistance to the mutagenic nucleoside analogue ribavirin (1-β-D-ribofuranosyl-1-H-1,2,4-triazole-3-carboxamide) is mediated by amino acid substitutions in the viral polymerase that either increase the general template copying...
Topics
- Adaptation, Physiological
- Amino Acid Sequence
- Amino Acid Substitution
- Antigens, Viral
- Antiviral Agents
- Drug Resistance, Viral
- Foot-and-Mouth Disease Virus
- Genes, Viral
- Molecular Sequence Data
- Mutation
- Nucleosides
- Protein Structure, Quaternary