Article
Lethal mutagenesis of HIV.
Virus research - 1 Feb 2005
Smith Robert A, Loeb Lawrence A, Preston Bradley D
Abstract excerpt
HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of "error catastrophe" or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here,...
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