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Article

Compensatory mutations modulate the competitiveness and dynamics of plasmid-mediated colistin resistance in Escherichia coli clones.

The ISME journal - 1 Mar 2020

Yang Qiu E, MacLean Craig, Papkou Andrei, Pritchard Manon, Powell Lydia, Thomas David, Andrey Diego O, Li Mei, Spiller Brad, Yang Wang, Walsh Timothy R

Abstract excerpt

The emergence of mobile colistin resistance (mcr) threatens to undermine the clinical efficacy of the last antibiotic that can be used to treat serious infections caused by Gram-negative pathogens. Here we measure the fitness cost of a newly discovered MCR-3 using in vitro growth and competition assays. mcr-3 expression confers a lower fitness cost than mcr-1, as determined by competitive ability and cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31896787
DOI: 10.1038/s41396-019-0578-6
PMCID: PMC7031280

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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