Article
Mutational analysis of an antimalarial drug target, PfATP4.
Proceedings of the National Academy of Sciences of the United States of America - 14 Jan 2025
Rachuri Swaksha, Nepal Binod, Shukla Anurag, Ramanathan Aarti, Morrisey Joanne M, Daly Thomas, Mather Michael W, Bergman Lawrence W, Kortagere Sandhya, Vaidya Akhil B
Abstract excerpt
Among new antimalarials discovered over the past decade are multiple chemical scaffolds that target Plasmodium falciparum P-type ATPase (PfATP4). This essential protein is a Na+ pump responsible for the maintenance of Na+ homeostasis. PfATP4 belongs to the type two-dimensional (2D) subfamily of P-type ATPases, for which no structures have been determined. To gain better insight into the structure/function...
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