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Article

Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport.

mBio - 1 Dec 2020

Calçada Carla, Silva Miguel, Baptista Vitória, Thathy Vandana, Silva-Pedrosa Rita, Granja Diana, Ferreira Pedro Eduardo, Gil José Pedro, Fidock David A, Veiga Maria Isabel

Abstract excerpt

Artemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia. The Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) transporter plays a central role in parasite resistance to ACT partner drugs through gene copy number variations (CNV)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33262257
DOI: 10.1128/mBio.02093-20
PMCID: PMC7733942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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