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Article

Structural and Functional Impact of the G340S Mutation in Plasmodium falciparum Ferredoxin NADP⁺ Reductase: In silico Analysis and Molecular Docking.

Gates open research - 1 Jan 2026

Kiboi Daniel, Muriithi Brenda

Abstract excerpt

Plasmodium falciparum, the deadliest malaria parasite, continues to burden health systems across sub-Saharan Africa, where artemether-lumefantrine remains a frontline treatment. Partial artemisinin resistance is emerging, increasing selection pressure on lumefantrine (LM), yet the molecular basis of reduced LM susceptibility remains poorly defined. While LM has been described as refractory to resistance, its...

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Topics

Plasmodium falciparum
Molecular Docking Simulation
Ferredoxin-NADP Reductase
Antimalarials
Drug Resistance
Lumefantrine

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Artemisinins

Mutation

Molecular Dynamics Simulation

NADP

Humans

Source

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Identifiers

PMID: 42723717
DOI: 10.12688/gatesopenres.16393.1
PMCID: PMC13553589

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