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Computational investigation of mutations in PfCRT and PfDHFR proteins for emerging resistance of Plasmodium falciparum to antimalarial drugs.

Molecular and biochemical parasitology - 1 Dec 2025

Ghosh Sushruta, Joshi Deepesh, Ponnusamy Chandra Sekar, Sridharan Bhavani, Velusamy Mahesh

Abstract excerpt

The emergence of multidrug resistance in Plasmodium falciparum poses a serious threat to antimalarial treatment, particularly with growing resistance to artemisinin-based combination therapies (ACTs) and partner drugs like piperaquine. Mutations in key proteins, such as PfCRT (P. falciparum chloroquine resistance transporter) and PfDHFR (P. falciparum dihydrofolate reductase), play a critical role in this...

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PMID: 40915500
DOI: 10.1016/j.molbiopara.2025.111700

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