Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial fission in apoptosis, neurodegeneration and aging.

Current opinion in cell biology - 1 Dec 2003

Bossy-Wetzel Ella, Barsoum Mark J, Godzik Adam, Schwarzenbacher Robert, Lipton Stuart A

Abstract excerpt

A decline in mitochondrial function is well recognized in neurodegenerative diseases and aging, and is thought to play a causal role in their biology. Unfortunately, the molecular basis underlying this detrimental loss in mitochondrial function remains mysterious. Interestingly, mitochondria undergo frequent fission and fusion. This process is regulated by molecular machinery that has been highly conserved during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Apoptosis
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila

Share to GTP Phosphohydrolases

Share to Mitochondria

Share to Neurodegenerative Diseases

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 14644195
DOI: 10.1016/j.ceb.2003.10.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial fission in apoptosis, neurodegeneration and aging.PMID 14644195Read ↗

Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration.Semantic proximity Read ↗

Emerging functions of mammalian mitochondrial fusion and fission.Semantic proximity Read ↗

Abnormalities of Mitochondrial Dynamics in Neurodegenerative DiseasesSemantic proximity Read ↗

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases.Semantic proximity Read ↗

Mitochondrial Dynamics in Brain Cells During Normal and Pathological AgingSemantic proximity Read ↗

[Mitochondrial morphology and dynamics: actors, mechanisms and functions].Semantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and DiseaseSemantic proximity Read ↗

The Balance of MFN2 and OPA1 in Mitochondrial Dynamics, Cellular Homeostasis, and Disease.Semantic proximity Read ↗

OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response.Semantic proximity Read ↗

Mitochondrial dynamics in neurodegeneration.Semantic proximity Read ↗

Mitochondrial dynamics and disease, OPA1.Semantic proximity Read ↗

Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.