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Article

Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence.

The Journal of biological chemistry - 3 Aug 2007

Lee Seungmin, Jeong Seon-Yong, Lim Won-Chung, Kim Sujeong, Park Yong-Yea, Sun Xuejun, Youle Richard J, Cho Hyeseong

Abstract excerpt

The number and morphology of mitochondria within a cell are precisely regulated by the mitochondrial fission and fusion machinery. The human protein, hFis1, participates in mitochondrial fission by recruiting the Drp1 into the mitochondria. Using short hairpin RNA, we reduced the expression level...

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Source

Identifiers

PMID: 17545159
DOI: 10.1074/jbc.M700679200

Genes

OPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17545159-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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