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Article

Mitochondrial DNA mutations provoke dominant inhibition of mitochondrial inner membrane fusion.

PloS one - 1 Jan 2012

Sauvanet Cécile, Duvezin-Caubet Stéphane, Salin Bénédicte, David Claudine, Massoni-Laporte Aurélie, di Rago Jean-Paul, Rojo Manuel

Abstract excerpt

Mitochondria are highly dynamic organelles that continuously move, fuse and divide. Mitochondrial dynamics modulate overall mitochondrial morphology and are essential for the proper function, maintenance and transmission of mitochondria and mitochondrial DNA (mtDNA). We have investigated mitochondrial fusion in yeast cells with severe defects in oxidative phosphorylation (OXPHOS) due to removal or various...

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Identifiers

PMID: 23166736
DOI: 10.1371/journal.pone.0049639
PMCID: PMC3500310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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