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Article

Mitochondrial fission, fusion, and stress.

Science (New York, N.Y.) - 31 Aug 2012

Youle Richard J, van der Bliek Alexander M

Abstract excerpt

Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by mixing the contents of partially damaged mitochondria as a form of complementation. Fission is needed to create new mitochondria, but it also contributes to quality control by enabling the removal of damaged mitochondria and can...

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PMID: 22936770
DOI: 10.1126/science.1219855
PMCID: PMC4762028

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