Article
Viral and cellular mRNA-specific activators harness PABP and eIF4G to promote translation initiation downstream of cap binding.
Proceedings of the National Academy of Sciences of the United States of America - 13 Jun 2017
Smith Richard W P, Anderson Ross C, Larralde Osmany, Smith Joel W S, Gorgoni Barbara, Richardson William A, Malik Poonam, Graham Sheila V, Gray Nicola K
Abstract excerpt
Regulation of mRNA translation is a major control point for gene expression and is critical for life. Of central importance is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-binding protein (PABP) that circularizes mRNAs, promoting translation and stability. This complex is often targeted to regulate overall translation rates, and also by mRNA-specific translational...
Topics
- Animals
- Eukaryotic Initiation Factor-4G
- Female
- Immediate-Early Proteins
- Models, Biological
- Mutation
- Oocytes
- Peptide Chain Initiation, Translational
- Poly(A)-Binding Proteins