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Article

Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation.

PLoS genetics - 1 Sept 2011

Lee Tom V, Fan Yun, Wang Shiuan, Srivastava Mayank, Broemer Meike, Meier Pascal, Bergmann Andreas

Abstract excerpt

Ubiquitylation targets proteins for proteasome-mediated degradation and plays important roles in many biological processes including apoptosis. However, non-proteolytic functions of ubiquitylation are also known. In Drosophila, the inhibitor of apoptosis protein 1 (DIAP1) is known to ubiquitylate the initiator caspase DRONC in vitro. Because DRONC protein accumulates in diap1 mutant cells that are kept alive by...

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Identifiers

PMID: 21909282
DOI: 10.1371/journal.pgen.1002261
PMCID: PMC3164697

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Source receipt: pubmed, retrieved 7 Sept 2026.

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