Article
The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism.
Cell death and differentiation - 1 Jun 2007
Tenev T, Ditzel M, Zachariou A, Meier P
Abstract excerpt
Apoptosis represents a fundamental biological process that relies on the activation of caspases. Inhibitor of apoptosis (IAP) proteins represent a group of negative regulators of both caspases and cell death. The current model dictates that IAPs suppress apoptosis by blocking the catalytic pocket of effector caspases thereby preventing substrate entry. Here, we provide evolutionary evidence for the functional...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.