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Article

IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.

Nature cell biology - 1 Jan 2005

Tenev Tencho, Zachariou Anna, Wilson Rebecca, Ditzel Mark, Meier Pascal

Abstract excerpt

Some members of the inhibitor of apoptosis (IAP) family suppress apoptosis by neutralizing caspases. The current model suggests that all caspase-regulatory IAPs function as direct enzyme inhibitors, blocking effector caspases by binding to their catalytically active pockets. Here we show that IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms. Whereas XIAP binds...

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Identifiers

PMID: 15580265
DOI: 10.1038/ncb1204

Genes

XIAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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