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Article

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.

Nature cell biology - 1 May 2003

Ditzel Mark, Wilson Rebecca, Tenev Tencho, Zachariou Anna, Paul Angela, Deas Emma, Meier Pascal

Abstract excerpt

Some members of the inhibitor of apoptosis (IAP) protein family block apoptosis by binding to and neutralizing active caspases. We recently demonstrated that a physical association between IAP and caspases alone is insufficient to regulate caspases in vivo and that an additional level of control is provided by IAP-mediated ubiquitination of both itself and the associated caspases. Here we show that Drosophila IAP...

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PMID: 12692559
DOI: 10.1038/ncb984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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