Article
Epithelial phenotypic changes are associated with a tubular active fibrogenic process in human renal grafts.
Human pathology - 1 Jul 2013
Xu-Dubois Yi-Chun, Baugey Edith, Peltier Julie, Colombat Magali, Ouali Nacéra, Jouanneau Chantal, Rondeau Eric, Hertig Alexandre
Abstract excerpt
Some recently published works contest the epithelial origin of myofibroblasts, which are the major extracellular matrix producers. However, our previous studies showed that, in tubular cells, some phenotypic changes reminiscent of epithelial-to-mesenchymal transition constitute an interesting early marker that predicts the progression of fibrosis in renal grafts. We hypothesized that activated epithelial cells...
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