Article
Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies.
Kidney international - 1 Jul 2002
Rastaldi Maria P, Ferrario Franco, Giardino Laura, Dell'Antonio Giacomo, Grillo Carlo, Grillo Paolo, Strutz Frank, Müller Gerhard A, Colasanti Giuliano, D'Amico Giuseppe
Abstract excerpt
BACKGROUND: In recent studies performed on cultured cells and experimental nephropathies, it has been hypothesized that tubular epithelial cells (TEC), via epithelial-mesenchymal transformation (EMT), can become collagen-producing cells. According to this theory, they should proceed through several activating steps, such as proliferation and phenotype changes, to eventually synthesize extracellular matrix (ECM)....
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