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Article

Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype.

Journal of molecular cell biology - 1 Jul 2020

Sarró Eduard, Durán Mónica, Rico Ana, Bou-Teen Diana, Fernández-Majada Vanesa, Croatt Anthony J, Nath Karl A, Salcedo Maria Teresa, Gundelach Justin H, Batlle Daniel, Bram Richard J, Meseguer Anna

Abstract excerpt

Restoration of kidney tubular epithelium following sublethal injury sequentially involves partial epithelial-mesenchymal transition (pEMT), proliferation, and further redifferentiation into specialized tubule epithelial cells (TECs). Because the immunosuppressant cyclosporine-A produces pEMT in TECs and inhibits the peptidyl-prolyl isomerase (PPIase) activity of cyclophilin (Cyp) proteins, we hypothesized that...

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Identifiers

PMID: 32162654
DOI: 10.1093/jmcb/mjaa005
PMCID: PMC7493029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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