Progression of pulse pressure in kidney recipients durably exposed to CsA is a risk factor for epithelial phenotypic changes: an ancillary study of the CONCEPT trial.

doi:10.1111/tri.12253

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Article

Progression of pulse pressure in kidney recipients durably exposed to CsA is a risk factor for epithelial phenotypic changes: an ancillary study of the CONCEPT trial.

Transplant international : official journal of the European Society for Organ Transplantation - 1 Apr 2014

Xu-Dubois Yi-Chun, Hertig Alexandre, Lebranchu Yvon, Hurault de Ligny Bruno, Thervet Eric, Jauréguy Maïté, Touchard Guy, Le Pogamp Patrick, Le Meur Yann, Toupance Olivier, Heng Anne-Elisabeth, Bayle Francis, Girardot-Seguin Sandrine, Servais Aude, Meas-Yedid Vannary, Rondeau Eric

Abstract excerpt

In this ancillary study of the CONCEPT trial, we studied the role of CsA withdrawal at 3 months (3M) post-transplant on the intensity of epithelial phenotypic changes (EPC, an early marker for kidney fibrogenesis) on the 12 M surveillance biopsy. Although conversion from CsA to sirolimus (SRL) at 3M was reported to have improved mean graft function at 12 M, it did not reduce the score of EPC (1.73 ± 1.15 in the...

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PMID: 24279707
DOI: 10.1111/tri.12253

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