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Article

Explanting is an ex vivo model of renal epithelial-mesenchymal transition.

Journal of biomedicine & biotechnology - 1 Jan 2011

Winbanks Catherine E, Darby Ian A, Kelynack Kristen J, Pouniotis Dodie, Becker Gavin J, Hewitson Tim D

Abstract excerpt

Recognised by their de novo expression of alpha-smooth muscle actin (SMA), recruitment of myofibroblasts is key to the pathogenesis of fibrosis in chronic kidney disease. Increasingly, we realise that epithelial-mesenchymal transition (EMT) may be an important source of these cells. In this study we describe a novel model of renal EMT. Rat kidney explants were finely diced on gelatin-coated Petri dishes and...

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Source

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Identifiers

PMID: 22162630
DOI: 10.1155/2011/212819
PMCID: PMC3227440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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