Article
The influence of tubular phenotypic changes on the development of diffuse interstitial fibrosis in renal allografts.
Transplantation proceedings - 1 Mar 2011
Özdemir B H, Özdemir A A, Colak T, Sezer S, Haberal M
Abstract excerpt
It has been reported that myofibroblasts are the major cells in the development of interstitial fibrosis (IF) and, therefore, chronic dysfunction in renal allografts. Our aim was two fold: first, to understand the key markers controlling tubular and glomerular epithelial-to-mesenchymal transition (EMT); second, to show the role of tubular EMT on the development of interstitial fibrosis (IF) and the role of...
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