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Article

Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2A receptor.

British journal of pharmacology - 1 Jul 2013

Bertheleme Nicolas, Singh Shweta, Dowell Simon J, Hubbard Julia, Byrne Bernadette

Abstract excerpt

BACKGROUND AND PURPOSE: Thermostabilization by mutagenesis is one method which has facilitated the determination of high-resolution structures of the adenosine A2A receptor (A(2A)R). Sets of mutations were identified, which both thermostabilized the receptor and resulted in preferential agonist (...

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Identifiers

PMID: 23489072
DOI: 10.1111/bph.12165
PMCID: PMC3696323

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23489072-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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