Evidence that purifying selection acts on promoter sequences.

Abstract excerpt

We tested whether functionally important sites in bacterial, yeast, and animal promoters are more conserved than their neighbors. We found that substitutions are predominantly seen in less important sites and that those that occurred tended to have less impact on gene expression than possible alternatives. These results suggest that purifying selection operates on promoter sequences.

Topics

• Animals
• Bacteria
• Computational Biology
• Conserved Sequence
• Evolution, Molecular
• Mutation
• Nucleotides
• Promoter Regions, Genetic
• Selection, Genetic
• Yeasts