Article
Diversification of CpG-Island Promoters Revealed by Comparative Analysis Between Human and Rhesus Monkey Genomes.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Aug 2020
Aoto Saki, Fushimi Mayu, Yura Kei, Okamura Kohji
Abstract excerpt
While CpG dinucleotides are significantly reduced compared to other dinucleotides in mammalian genomes, they can congregate and form CpG islands, which localize around the 5' regions of genes, where they function as promoters. CpG-island promoters are generally unmethylated and are often found in housekeeping genes. However, their nucleotide sequences and existence per se are not conserved between humans and...
Topics
- Animals
- Base Sequence
- CpG Islands
- DNA Methylation
- Epigenesis, Genetic
- Genetic Variation
- Genome
- Genome, Human
- Genomics
- Humans
- INDEL Mutation
- Macaca mulatta
- Mammals
- Mice
- Mutation