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Article

A novel test for selection on cis-regulatory elements reveals positive and negative selection acting on mammalian transcriptional enhancers.

Molecular biology and evolution - 1 Nov 2013

Smith Justin D, McManus Kimberly F, Fraser Hunter B

Abstract excerpt

Measuring natural selection on genomic elements involved in the cis-regulation of gene expression--such as transcriptional enhancers and promoters--is critical for understanding the evolution of genomes, yet it remains a major challenge. Many studies have attempted to detect positive or negative...

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Share to Computational Biology
Share to Enhancer Elements, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Mammals

Share to Regulatory Elements, Transcriptional

Share to Regulatory Sequences, Nucleic Acid

Share to Selection, Genetic

Source

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Identifiers

PMID: 23904330
DOI: 10.1093/molbev/mst134
PMCID: PMC3808868

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23904330-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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