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Article

Housekeeping genes tend to show reduced upstream sequence conservation.

Genome biology - 1 Jan 2007

Farré Domènec, Bellora Nicolás, Mularoni Loris, Messeguer Xavier, Albà M Mar

Abstract excerpt

BACKGROUND: Understanding the constraints that operate in mammalian gene promoter sequences is of key importance to understand the evolution of gene regulatory networks. The level of promoter conservation varies greatly across orthologous genes, denoting differences in the strength of the evolutionary constraints. Here we test the hypothesis that the number of tissues in which a gene is expressed is related in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17626644
DOI: 10.1186/gb-2007-8-7-r140
PMCID: PMC2323216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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