An effective model for natural selection in promoters.

Abstract excerpt

We have produced an evolutionary model for promoters, analogous to the commonly used synonymous/nonsynonymous mutation models for protein-coding sequences. Although our model, called Sunflower, relies on some simple assumptions, it captures enough of the biology of transcription factor action to show clear correlation with other biological features. Sunflower predicts a binding profile of transcription factors to...

Topics

• Algorithms
• Animals
• Base Sequence
• Binding Sites
• Dogs
• Evolution, Molecular
• Gene Expression Regulation
• Genome
• Genome, Human
• Humans
• Markov Chains
• Models, Genetic
• Mutation
• Promoter Regions, Genetic
• Selection, Genetic
• Transcription Factors