Article
Transgenic animal models in toxicology: historical perspectives and future outlook.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2011
Boverhof Darrell R, Chamberlain Mark P, Elcombe Clifford R, Gonzalez Frank J, Heflich Robert H, Hernández Lya G, Jacobs Abigail C, Jacobson-Kram David, Luijten Mirjam, Maggi Adriana, Manjanatha Mugimane G, Benthem Jan van, Gollapudi B Bhaskar
Abstract excerpt
Transgenic animal models are powerful tools for developing a more detailed understanding on the roles of specific genes in biological pathways and systems. Applications of these models have been made within the field of toxicology, most notably for the screening of mutagenic and carcinogenic potential and for the characterization of toxic mechanisms of action. It has long been a goal of research toxicologists to...
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