Article
Pharmacogenetics of soluble sulfotransferases (SULTs).
Naunyn-Schmiedeberg's archives of pharmacology - 1 Jan 2004
Glatt Hansruedi, Meinl Walter
Abstract excerpt
Soluble sulfotransferases (SULTs) transfer the sulfo group from the cofactor 5'-phosphoadenosine-3'-phosphosulfate (PAPS) to nucleophilic sites of relatively small acceptor molecules including various hormones and numerous xenobiotics. Sulfo conjugation of xenobiotics can lead to the formation of polar, excretable products as well as reactive, potentially mutagenic and carcinogenic metabolites. Ten SULT genes...
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