Article
The leucine zipper domain of avian cMyc is required for transformation and autoregulation.
Oncogene - 1 May 1990
Crouch D H, Lang C, Gillespie D A
Abstract excerpt
Small deletions of 7 to 48 amino acids have been generated in the leucine zipper domain of the avian cMyc protein and the mutant cMyc proteins expressed using an avian retroviral vector. Retrovirally encoded cMyc protein transforms primary chick embryo fibroblasts and leads to abnormal regulation of the endogenous c-myc gene. Deletion of the most C-terminal leucine of the zipper motif confers a partial phenotype...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Chick Embryo
- DNA
- Fibroblasts
- Gene Expression Regulation
- Homeostasis
- Leucine
- Molecular Sequence Data
- Phenotype
- Proto-Oncogene Proteins