Article
Multiple phenotypes associated with Myc-induced transformation of chick embryo fibroblasts can be dissociated by a basic region mutation.
Nucleic acids research - 15 Aug 1996
Crouch D H, Gallagher R, Goding C R, Neil J C, Fulton R
Abstract excerpt
Chimaeric alleles were constructed to assay the biological functions of an N-terminal deletion and C-terminal mutations which were found in a naturally occurring mutant of feline vMyc, T17. The mutant alleles were assayed for their ability to transform chick embryo fibroblasts in vitro by a numbe...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Binding Sites
- Cats
- Cell Transformation, Neoplastic
- Chick Embryo
- DNA-Binding Proteins
- Genes, myc
- Molecular Sequence Data
- Mutation
- Oncogene Protein p55(v-myc)
- Phenotype
- Protein Binding
- Protein Structure, Secondary
- Proto-Oncogene Proteins c-myc
- Recombinant Fusion Proteins
- Sequence Deletion