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Article

N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation.

Genes & development - 1 Jun 2000

Malynn B A, de Alboran I M, O'Hagan R C, Bronson R, Davidson L, DePinho R A, Alt F W

Abstract excerpt

Members of the myc family of cellular oncogenes have been implicated as transcriptional regulators in pathways that govern cellular proliferation and death. In addition, N-myc and c-myc are essential for completion of murine embryonic development. However, the basis for the evolutionary conservation of myc gene family has remained unclear. To elucidate this issue, we have generated mice in which the endogenous...

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Identifiers

PMID: 10837031
PMCID: PMC316670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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