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Article

Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.

Molecular and cellular biology - 1 Sept 1990

Penn L J, Brooks M W, Laufer E M, Littlewood T D, Morgenstern J P, Evan G I, Lee W M, Land H

Abstract excerpt

Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essential carboxyl-terminal region harbors structural motifs (a basic region, a helix-loop-helix motif,...

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Identifiers

PMID: 2201910
DOI: 10.1128/mcb.10.9.4961-4966.1990
PMCID: PMC361121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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