Article
Domains of human c-myc protein required for autosuppression and cooperation with ras oncogenes are overlapping.
Molecular and cellular biology - 1 Sept 1990
Penn L J, Brooks M W, Laufer E M, Littlewood T D, Morgenstern J P, Evan G I, Lee W M, Land H
Abstract excerpt
Amino acids 106 to 143 and 354 to 433 of the human c-myc protein (439 amino acids) were shown to be required for the protein to suppress c-myc gene transcription and were found to exactly overlap with those necessary for c-myc to cooperate with ras oncogenes in the transformation of rat embryo fibroblasts. The essential carboxyl-terminal region harbors structural motifs (a basic region, a helix-loop-helix motif,...
Topics
- Animals
- Cell Line
- Genes, ras
- Humans
- Mutation
- Protein Conformation
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-myc
- Proto-Oncogenes
- Rats