Article
Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited.
Oncogene - 19 Jul 2001
Langa F, Lafon I, Vandormael-Pournin S, Vidaud M, Babinet C, Morello D
Abstract excerpt
c-Myc is a protooncogene involved in the control of cellular proliferation, differentiation and apoptosis. Like many other early response genes, regulation of c-myc expression is mainly controlled at the level of mRNA stability. Multiple cis-acting destabilizing elements have been described that are located both in the protein-coding region and in the 3' untranslated region (3' UTR). However, it is not known when...
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