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Article

Enhanced self-renewal capability in hepatic stem/progenitor cells drives cancer initiation.

Gastroenterology - 1 Sept 2007

Chiba Tetsuhiro, Zheng Yun-Wen, Kita Kaoru, Yokosuka Osamu, Saisho Hiromitsu, Onodera Masafumi, Miyoshi Hiroyuki, Nakano Masayuki, Zen Yoh, Nakanuma Yasuni, Nakauchi Hiromitsu, Iwama Atsushi, Taniguchi Hideki

Abstract excerpt

BACKGROUND & AIMS: Transformed hematopoietic stem/progenitor cells with an enhanced or acquired self-renewal capability function as leukemic stem cells. In a variety of solid cancers, stem/progenitor cells could be also targets of carcinogenesis. However, it remains unclear whether disruption of stem cell function directly contributes to cancer initiation. We sought to elucidate the mechanisms of self-renewal in...

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Identifiers

PMID: 17673212
DOI: 10.1053/j.gastro.2007.06.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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