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Essential roles for Pot1b in HSC self-renewal and survival

24 Sept 2011

Abstract excerpt

Maintenance of mammalian telomeres requires both the enzyme telomerase and shelterin, which protect telomeres from inappropriately activating DNA damage response checkpoints. Dyskeratosis congenita is an inherited BM failure syndrome disorder because of defects in telomere maintenance. We have previously shown that deletion of the shelterin component Pot1b in the setting of telomerase haploinsufficiency results...

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Share to DNA Repair Mechanisms
Share to Nuclear Structure and Function
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21948176
DOI: 10.1182/blood-2011-06-361527

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Essential roles for Pot1b in HSC self-renewal and survivalPMID 21948176Read ↗

The telomere binding protein Pot1 maintains haematopoietic stem cell activity with ageSemantic proximity Read ↗

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