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Article

Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion.

PLoS biology - 1 Jan 2013

Kent David G, Li Juan, Tanna Hinal, Fink Juergen, Kirschner Kristina, Pask Dean C, Silber Yvonne, Hamilton Tina L, Sneade Rachel, Simons Benjamin D, Green Anthony R

Abstract excerpt

Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors. Human myeloproliferative neoplasms (MPNs) are thought to reflect transformation of a hematopoietic stem cell (HSC) and the majority harbor an acquired V617F mutation in the JAK2 tyrosine kinase,...

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Identifiers

PMID: 23750118
DOI: 10.1371/journal.pbio.1001576
PMCID: PMC3672217

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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