Article
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2008
Gan Boyi, Sahin Ergün, Jiang Shan, Sanchez-Aguilera Abel, Scott Kenneth L, Chin Lynda, Williams David A, Kwiatkowski David J, DePinho Ronald A
Abstract excerpt
The Tuberous Sclerosis Complex component, TSC1, functions as a tumor suppressor via its regulation of diverse cellular processes, particularly cell growth. TSC1 exists in a complex with TSC2 and functions primarily as a key negative regulator of mammalian target of rapamycin complex 1 (mTORC1) signaling and protein synthesis, although the TSC1/TSC2 complex also shows mTORC1-independent outputs to other pathways....
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