Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

doi:10.1038/s41467-021-22053-y

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Article

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway.

Nature communications - 23 Mar 2021

Fujino Takeshi, Goyama Susumu, Sugiura Yuki, Inoue Daichi, Asada Shuhei, Yamasaki Satoshi, Matsumoto Akiko, Yamaguchi Kiyoshi, Isobe Yumiko, Tsuchiya Akiho, Shikata Shiori, Sato Naru, Morinaga Hironobu, Fukuyama Tomofusa, Tanaka Yosuke, Fukushima Tsuyoshi, Takeda Reina, Yamamoto Keita, Honda Hiroaki, Nishimura Emi K, Furukawa Yoichi, Shibata Tatsuhiro, Abdel-Wahab Omar, Suematsu Makoto, Kitamura Toshio

Abstract excerpt

Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examined the influence of ASXL1-MT on physiological aging in hematopoietic stem cells (HSCs). HSCs expressing ASXL1-MT display competitive disadvantage after...

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PMID: 33758188
DOI: 10.1038/s41467-021-22053-y
PMCID: PMC7988019

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