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Role of 657del5 NBN mutation and 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B) and 14q11.2 (CEBPE) variation and risk of childhood ALL in the Polish population.

Leukemia research - 1 Nov 2011

Pastorczak Agata, Górniak Patryk, Sherborne Amy, Hosking Fay, Trelińska Joanna, Lejman Monika, Szczepański Tomasz, Borowiec Maciej, Fendler Wojciech, Kowalczyk Jerzy, Houlston Richard S, Młynarski Wojciech

Abstract excerpt

Recent studies have shown that SNPs mapping to 7p12.2 (IKZF1), 9p21 (CDKN2A), 10q21.2 (ARID5B), and 14q11.2 (CEBPE) and carrier status for recessively inherited Nijmegen Breakage syndrome (NBS) influence childhood acute lymphoblastic leukemia (ALL) risk. To examine these relationship, we analysed 398 ALL cases and 731 controls from Poland. Statistically significant association between genotype at 7p12.2 (IKZF1),...

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PMID: 21889209
DOI: 10.1016/j.leukres.2011.07.034

Genes

IKZF1
NBN

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