Article
Association of three polymorphisms in ARID5B, IKZF1 and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population.
Gene - 25 Jul 2013
Wang Yaping, Chen Jing, Li Jie, Deng Jianping, Rui Yaoyao, Lu Qin, Wang Meilin, Tong Na, Zhang Zhengdong, Fang Yongjun
Abstract excerpt
Recent genome-wide association studies (GWAS) that focus on childhood acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2) and CEBPE (14q11.2) are strongly related to the risk of childhood ALL. These polymorphisms may lead to abnormal expression and dysfunction of...
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