Article
Association of genetic variation in IKZF1, ARID5B, CDKN2A, and CEBPE with the risk of acute lymphoblastic leukemia in Tunisian children and their contribution to racial differences in leukemia incidence.
Pediatric hematology and oncology - 1 Apr 2016
Gharbi Hanene, Ben Hassine Islem, Soltani Ismail, Safra Ines, Ouerhani Slah, Bel Haj Othmen Hind, Teber Mouheb, Farah Ahlem, Amouri Hassiba, Toumi Nourel Houda, Abdennebi Salima, Abbes Salem, Menif Samia
Abstract excerpt
Recent genome-wide association studies (GWAS) focusing on pediatric acute lymphoblastic leukemia (ALL), the most common malignancy in children younger than 15 years old, have found evidence that single-nucleotide polymorphisms (SNPs) in IKZF1 (7p12.2), ARID5B (10q21.2), CDKN2A (9p21.3), and CEBPE (14q11.2) are strongly associated to the risk of developing pediatric ALL. These studies have been conducted in...
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