Article
Identification of novel variants in LRRK2 gene in patients with Parkinson's disease in Serbian population.
Journal of the neurological sciences - 1 Jan 2015
Janković Milena Z, Kresojević Nikola D, Dobričić Valerija S, Marković Vladana V, Petrović Igor N, Novaković Ivana V, Kostić Vladimir S
Abstract excerpt
BACKGROUND: Mutations in LRRK2 (leucine-rich repeat kinase 2) are the most common cause of autosomal dominant Parkinson's disease (PD). Large international studies have revealed that pathogenic mutations are clustered in several exons coding for functional domains of LRRK2 protein, but the mutati...
Topics
- Adult
- Aged
- DNA Mutational Analysis
- Exons
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged